We stayed in Plakias with First Choice this year and hired a car through them with Europcar, although probably more expensive than the local outlets even at 4 days for the price of 2 (196Euro's).
As part of the deal the rep Afroditi, who was an excellent rep by the way, said she could arrange a free overnight stop elsehere on the island if we wanted.
Consequently we had 2 days in the Chania area staying in an excellent First Choice appartment in Platanias just outside the main town. The local rep said we could have stayed on for more nights but we had to get back.
By car from Plakias I would say Chania is about 1.5 hours. The town itself is interesting particularly around the harbour and the old town back streets.
The beaches on the western side are fantastic, we particularly liked Falisarna. The Akrotiri peninsula has a nice beach at the extreme end called Stavros.
For 2 weeks I would still prefer Plakias to the Chania resorts, which are very touristy, but it makes for a great diversion and change of scenery.
Martinh